Causes of AML
The pathogenesis of AML is still unclear, but a double mechanism has been suggested as a probable cause for leukemogenesis. That means that AML could be the consequence of at least two different types of acquired genetic mutations. While the exact cause of acute myeloid leukemia is unknown, a number of associated risk factors have been identified:
The risk factors associated with acute myeloid leukemia are:
1) Exposure to chemical agents
Some studies have determined that exposure to high doses of benzene increases the risk of developing acute myeloid leukemia. Benzene is a chemical that was previously used in industries that manufactured plastics, resins, and other chemicals. Although its use is not as prevalent as before, it is still widely used to make adhesives, lubricants, dyes, detergents, and pesticides. Various studies have been carried out to try to establish a connection between exposure to these substances in the work environment and the development of AML. Still, no conclusive data has yet been obtained.