Chronic lymphocytic leukemia treatment
Treatment for chronic lymphocytic leukemia is not required unless patients have symptoms such as extreme fatigue, weight loss of 10% or more over the last 6 months, fever for 2 weeks or more, massive lymphadenopathies, autoimmune anemia, thrombocytopenia that does not respond to steroids, and progressive lymphocytosis of 50% in two months.
When necessary, treatment includes chemotherapy that combines alkylating agents, nucleoside analogs, and biologic agents. The only way to cure the disease is through allogeneic stem cell transplantation, and remission of the disease is defined by a total absence of lymphadenopathy, lymphocytosis, and organ enlargement.
Nabhan, C., & Rosen, S. T. (2014). Chronic lymphocytic leukemia: a clinical review. Jama, 312(21), 2265-2276.
Slager, S. L., & Kay, N. E. (2009). Familial chronic lymphocytic leukemia: what does it mean to me?. Clinical Lymphoma and Myeloma, 9, S194-S197.
Hallek, M., Cheson, B. D., Catovsky, D., Caligaris-Cappio, F., Dighiero, G., Döhner, H., … & Kipps, T. J. (2008). Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute–Working Group 1996 guidelines. Blood, The Journal of the American Society of Hematology, 111(12), 5446-5456.
Wang, L., Lawrence, M. S., Wan, Y., Stojanov, P., Sougnez, C., Stevenson, K., … & Zhang, W. (2011). SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. New England Journal of Medicine, 365(26), 2497-2506.