Chronic Myeloid Leukemia (CML) – Everything You Need To Know!

5. Hemorrhagic manifestations

Bleeding
Hemorrhagic manifestations

They are only seen in later stages of the disease and the acute subtype of leukemia. In these cases, the bone marrow becomes dysfunctional, and other cell lines become affected, including the number and function of circulating platelets.


In general, we can say that chronic myeloid leukemia is a slow-progressing disease, and the majority of patients are diagnosed in a later phase of the disease. However, there are three primary phases, each one with its own characteristics. The first one is called the chronic phase, the second one is the accelerated phase, and the third one is the blast phase.

During the chronic phase, we have a proliferation of mature cells, and patients may not display severe signs and symptoms. During the accelerated phase, additional genetic abnormalities are causing the disease to become rapidly progressing. And then, in the blast phase, there’s a very rapid proliferation of immature cells, and patients start having severe and often life-threatening health problems.

It is also important to note that the symptoms and the progression of the disease sometimes depend on the age of the patient. Unfortunately, a more aggressive disease usually strikes younger patients diagnosed with chronic myeloid leukemia. They progress to the accelerated and blast phase faster than middle-aged patients and should be treated promptly.