2) Liver manifestations
The liver is a silent organ and liver diseases do not cause symptoms unless severe and sudden. Therefore, in many cases, liver affection goes unnoticed, but in more severe cases, jaundice may develop. Jaundice occurs when a large portion of the liver is destroyed, and it can’t process the normal bilirubin resulting from the normal destruction of red blood cells. Bilirubin is yellow and attaches to elastic tissue and collagen found in the sclera or “the white of the eye” and the skin. Another rare manifestation of liver disease is coma.
Hepatic coma results from the accumulation of ammonia and manganese, which it normally excretes and processes. They act on brain cells causing a variety of manifestations including loss of coordination, short-term memory, confusion, disorientation or behavioral changes.