Anti-Rh
We all know that blood groups are given names like A+ or O-. The names are derived from proteins found on the surface of our red blood cells called antigens. For example, an A+ individual has an A antigen as well as an Rh (+) antigen. They also have antibodies against the B antigens, and this is the basis of blood transfusion matching. In case of Rh-positive individuals, we can inject them to hold on to red blood cells and destroy them using the same system used to destroy platelets. In other words, we sacrifice red blood cells to save the platelets. It may seem strange, but the number of red blood cells and their size are far greater than those of platelets, which turns the effect upon red blood cells minimal.
In adults who had ITP for more than three months, different therapeutic regimens are considered including chemotherapy like rituximab which acts as an immunosuppressive or more recent drugs called TPO-RA. TPO-RA is short for thrombopoietin receptor agonists. These drugs act as the hormone thrombopoietin in stimulating the bone marrow to produce more platelets. The current members of this class are romiplastin and eltrombopag.