Splenectomy
Splenectomy is the surgical removal of the spleen. It can be resorted to in some cases of ITP if other therapies prove ineffective, especially in adults. The idea is that the spleen is the main site of platelet destruction after being coated with autoantibodies, and its removal will decrease their destruction. In fact, it is one of the most effective therapies and platelet count increases rapidly following such therapy. Splenectomy, however, has some drawbacks, including a decreased immunity towards certain bacteria. Therefore, it is left as a last resort and several precautions are done before and after its removal, including the use of vaccines against such organisms and antibiotics.