Is immunotherapy painful?
One of the main concerns of patients undergoing immunotherapy is whether the treatment is painful. This stems from their experience with some chemotherapeutic drugs which tend to be irritant to the skin and veins causing painful thrombosis ulceration at their site of injection. Immunotherapy, on the other hand, is not irritant to blood vessels and tends to not leave scars at its site of injection. However, the risk of skin reactions can be high in some types of immunotherapy especially in checkpoint inhibitors.
Activation of the immune system can occur at the site of injection causing skin rash, redness, itching, and mild edema. It tends to be self-limited and your doctor will prescribe creams and topical applications to alleviate any pain or itch you might have.