Signs and symptoms
In some cases, myelodysplastic syndromes are not clinically apparent for many years. The symptomatic myelodysplastic disease is sometimes preceded by sustained macrocytic anemia for many years and mild neutropenia or thrombocytopenia. The most prevalent signs and symptoms depend on the course of the disease, and are as follows:
1) Fatigue
Chronic fatigue is common in MDS. It results from anemia and increased metabolic rate due to chronic disease. Some patients have chronic heart failure and other cardiac causes of fatigue.