Myelofibrosis diagnosis
Diagnosing myeloproliferative neoplasms in general relies on good history taking and examination supplemented by blood tests. Your doctor will ask you about your symptoms and will order needed tests.
1) Physical examination
Your doctor will examine your skin for signs of hemorrhage and your eyes and hands for the paleness of anemia. They will also examine your abdomen searching for an enlarged spleen and liver, as well as your joints for signs of gout. They may also check your enlarged lymph nodes since they may become larger as a manifestation of extramedullary erythropoiesis or for differentiating it from other malignant conditions that may or may not be a result of myelofibrosis like acute leukemias.