2) Hydroxyurea
Hydroxyurea is one of the oldest chemotherapeutic agents to be used for hematological malignancies, and it is still used in myelofibrosis. It acts mainly as a nonspecific cytoreductive agent, which means that it decreases the number of excessive blood cells like megakaryocytes and red cells which ultimately can result in remission. This class of chemotherapeutic agents is still very non specific that they can even cause severe cellular deficiencies in the form of bone marrow toxicity, but it can’t be replaced due to the fact that even the targeted therapy (ruxolitinib) isn’t successful in many cases.