Myelofibrosis symptoms
One of the challenges for the treatment of myelofibrosis is that many patients don’t show any symptoms, since the anemia is usually compensated for by the extramedullary erythropoiesis. Otherwise, symptoms can be a result of anemia, splenic enlargement, increased cellular production and the energy it requires or deficiency of platelets. The following symptoms are the most common:
1) Splenic enlargement manifestations
The spleen is an organ located just below your diaphragm in the upper left part of your abdomen. When it enlarges, it usually produces no symptoms, however, rapid or massive enlargement can be troublesome. Rapid enlargement can cause pressure upon the capsule of the spleen and a characteristic type of pain called stitching pain. If the spleen enlarges to a massive size, it can also pull the ligament holding it to the diaphragm producing a feeling of heaviness and pain.