3) Hypersplenism
The spleen enlarges to be able to produce more red blood cells. However, this can turn up to be a double-edged weapon since the spleen is also the main site of the destruction of aged cells. Its enlargement carries the risk of causing hypersplenism when it destroys red blood cells, exaggerating the condition it was meant to resolve. It can also destroy white blood cells and platelets causing decreased counts and increased susceptibility to infections and bleeding tendency.