Myelofibrosis | Myelofibrosis Symptoms, Diagnosis & Myelofibrosis Treatment

7) Gout and kidney stones

When metabolism is excessive and large numbers of cells are destroyed on a daily basis, their basic components are metabolized extensively. The DNA of cells is formed by small units called purines and pyrimidines. Purines re metabolized to uric acid which if excessive, can deposit in body’s tissues especially joints causing the characteristic pain and swelling of joints of the leg and arm “gouty arthritis”. Uric acid is also excreted in large amount in urine causing ureter stones and even in severe cases, kidney failure.