6) Cyclosporine:
Cyclosporine is a potent immunosuppressant which acts on a receptor called calcineurin and causes immunosuppression of both types of immunity. As can be expected such dramatic response in psoriasis is also coupled with profound immunosuppression which puts the body at the mercy of countless bacteria and viruses. This is why cyclosporine is not used continuously but rather as pulse therapy to achieve quick response in some cases that fail to respond to other medications. It can be used in combination with other therapies and withdrawn later.