Systemic mastocytosis (SM)
There are many types of white blood cells, and one of them is called mast cells. These are important to improve healing properties and during the process of immune response and allergies. When too many mast cells build up in the blood, it is called mastocytosis. In systemic mastocytosis, excess mast cells start causing problems throughout the gastrointestinal tract, causing diarrhea, nausea, and vomiting. It is a bone marrow problem, similar to leukemia and myelodysplastic syndromes, so the best way to diagnose is by taking a bone marrow sample and performing a biopsy.
As you have probably seen, leukemia and other syndromes associated with bone marrow dysfunction often feature a reduction of cells in the blood. The signs and symptoms are according to the phase of the disease and the subtype, and the age of onset is quite variable depending on each patient.
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