4) Imaging studies
They are very useful to evaluate splenomegaly and hepatomegaly in mild forms of hairy cell leukemia. In the majority of cases, they are palpable and encountered in physical examination. However, when a measurement is required, ultrasound will be the most appropriate scan.
Additionally, it is possible to include either immunohistochemistry studies or flow cytometry to distinguish hairy cell leukemia with other types of B-cell lymphoid leukemia. It is possible to test for genetic mutations, in which case it is useful to search for the BRAF-V600E mutation.