Hairy cell leukemia prognosis
Hairy cell leukemia is a type of chronic leukemia, and it is a long-standing disease with a slow progression and a high survival rate. Survival after 5 years is as high as 94% and higher in Whites as compared to African Americans.
However, patients with hairy cell leukemia have a very high chance of developing a second malignancy. The most common second malignancy is skin cancer, which can be sometimes melanoma. Other common malignancies include colon cancer, prostate cancer, lymphoma, and breast cancer. Up to 31% of patients with hairy cell leukemia develop a second malignancy, and some of them were diagnosed before hairy cell leukemia.
Risk stratification of hairy cell leukemia depends on the severity of pancytopenia, the presence of lymphadenopathy, and the presence of additional mutations in the TP53 gene.