3) Enlargement of the liver and spleen
Both the liver and spleen are a part of the reticuloendothelial system which is responsible for the destruction of aged cells and -in some cases- the formation of new cells for the blood if the conditions demand. In lymphomas, they may also enlarge since some lymphoma cells can filter through them or some lymphocytes within their tissue may become malignant since they are exposed to the same stimuli as lymph nodes.