3) Bone marrow biopsy or aspiration
An important phase of the diagnosis is the aspiration or biopsy of the bone marrow. In this test, it is possible to perform the immunophenotypic profile of the B-cells. They will be positive for certain surface proteins (CD11c, CD25, CD103, and CD123) and negative or very dim for others (CD5, CD10, CD23, CD27, CD79b).