3. Sickle cell anemia
Sickle cell anemia is characterized by the sickle-shaped red cells which occlude blood vessels producing severe pain of the limbs. Splenectomy is generally rare in sickle cell anemia because the spleen suffers from such vascular occlusions causing it to die slowly and disappear, a condition called auto-splenectomy, however one complication of sickle cell anemia called splenic sequestration crisis may occur when the splenic venous drainage is occluded by red cells, causing the spleen to “pool” large amounts of blood leading to a severe drop of blood pressure. This condition usually necessitates emergency splenectomy.