E) Medical therapy for bone disease
Some drugs have been advocated for the skeletal disease in multiple myeloma. They function to decrease the normal osteoclastic activity of the bone. Our bones are in a continuous state of destruction and formation. Destruction is carried out by cells called osteoclasts while formation is done by cells called osteoblasts. On decreasing osteoclastic activity, the rate of bone destruction decreases, and the amount of calcium released into the circulation is decreased. Two main drugs serve this purpose: bisphosphonates and denosumab.