2) Bone pain and fractures
Up to half the patients with multiple myeloma present with problems related to their skeletal system. Due to the rapid growth and division of multiple myeloma, it “eats” through the bone and causes it to weaken, making it susceptible to fracture with minor or no trauma. This is called a pathological fracture. Due to the rapid expansion of the myeloma in the bone marrow cavity, the pain-sensitive covering of the bone “the periosteum” becomes irritated leading to pain which can be severe.